NHS Dudley Health Economy Medicines Formulary
Home > 2 Cardiovascular system > 2.5 Hypertension and heart failure > 2.5.2 Centrally acting antihypertensive drugs

2.5.2 Centrally acting antihypertensive drugs

General guidance

  • Methyldopa is considered the agent of choice in pregnancy.
  • Sudden withdrawal of clonidine can precipitate a hypertensive crisis.
  • Moxonidine has been recently introduced for mild to moderate essential hypertension. It may have a role when thiazides, beta-blockers, ACE inhibitors and calcium channel blockers are not appropriate or have failed to adequately control blood pressure.


Drug Traffic Light Key:

Green – On Formulary

Amber – Restricted use, see local guidelines      

Purple – Specialist use/initiation

Red – Non Formulary


Relative Costs Key (where indicated):

£££££ - high

£££ - moderate

£ - low

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