NHS Dudley Health Economy Medicines Formulary
Home > 3 Respiratory system > 3.7 Mucolytics

3.7 Mucolytics

General guidance

  • Mucolytics are sometimes prescribed to facilitate expectoration by reducing sputum viscosity in chronic asthma and bronchitis. However, efficacy data is generally lacking and their use should be avoided.
  • Steam inhalation with postural drainage, is good expectorant therapy in bronchiectasis and chronic bronchitis.
  • Dornase alfa is used in cystic fibrosis, it should only be initiated and treatment assessed by suitable specialists.

Recommended drugs

Dornase Alfa


N-Acetylcysteine for patients with fibrosing alveolitis 


Drug Traffic Light Key:

Green – On Formulary

Amber – Restricted use, see local guidelines      

Purple – Specialist use/initiation

Red – Non Formulary


Relative Costs Key (where indicated):

£££££ - high

£££ - moderate

£ - low

Site by Devopa
© Copyright 2024 NHS. All rights reserved.