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Formulary Home
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1 Gastro-intestinal system
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2 Cardiovascular system
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3 Respiratory system
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4 Central nervous system
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5 Infections
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6 Endocrine system
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7 Obstetrics, gynaecology, and urinary-tract disorders
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8 Malignant disease and immunosuppression
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8.1 Cytotoxic drugs
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8.1.1 Alkylating drugs
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8.1.2 Anthracyclines and other cytotoxic antibiotics
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8.1.3 Antimetabolites
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8.1.4 Vinca alkaloids and etoposide
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8.1.5 Other antineoplastic drugs
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Guidance on the use of temozolomide for the treatment of recurrent malignant glioma (brain cancer) - NICE TAG TA23
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Breast cancer - trastuzumab - NICE TAG TA34
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Dual‑chamber pacemakers for symptomatic bradycardia due to sick sinus syndrome and/or atrioventricular block- NICE TAG TA55
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Gastrointestinal stromal tumours - imatinib - NICE TAG TA86
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Ovarian cancer (advanced) - paclitaxel, pegylated liposomal doxorubicin hydrochloride and topotecan (review) - NICE TAG TA91
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Prostate cancer (hormone-refractory) - docetaxel - NICE TAG TA101
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Breast cancer (early) - trastuzumab - NICE TAG TA107
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Breast cancer (early) - paclitaxel - NICE TAG TA108
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Breast cancer (early) - docetaxel - NICE TAG TA109
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Bevacizumab and cetuximab for the treatment of metastatic colorectal cancer- NICE TAG TA118
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Glioma (newly diagnosed and high grade) - carmustine implants and temozolomide - NICE TAG TA121
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Multiple myeloma - bortezomib - NICE TAG TA129
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Head and neck cancer - cetuximab - NICE TAG TA145
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Lung cancer (non-small-cell) - erlotinib - NICE TAG TA162
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Renal cell carcinoma - sunitinib - NICE TAG TA169
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Head and neck cancer (squamous cell carcinoma) - cetuximab - NICE TAG TA172
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Colorectal cancer (first line) - cetuximab - NICE TAG TA176
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Renal cell carcinoma - NICE TAG TA178
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Gastrointestinal stromal tumours - sunitinib - NICE TAG TA179
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Cervical cancer (recurrent) - topotecan - NICE TAG TA183
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Lung cancer (small-cell) - topotecan - NICE TAG TA184
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Soft tissue sarcoma - trabectedin - NICE TAG TA185
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Hepatocellular carcinoma (advanced and metastatic) - sorafenib (first line) - NICE TAG TA189
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Lung cancer (non-small-cell, first line) - gefitinib - NICE TAG TA192
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Gastrointestinal stromal tumours - imatinib (adjuvant) - NICE TAG TA196
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Gastric cancer (HER2-positive metastatic) - trastuzumab - NICE TAG TA208
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Gastrointestinal stromal tumours (unresectable/metastatic) - imatinib - NICE TAG TA209
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Colorectal cancer (metastatic) - bevacizumab - NICE TAG TA212
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Breast cancer - bevacizumab (in combination with a taxane) - NICE TAG TA214
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Pazopanib for the first-line treatment of advanced renal cell carcinoma - NICE TAG TA215
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Everolimus for the second-line treatment of advanced renal cell carcinoma - NICE TAG TA219
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Ovarian cancer (relapsed) - trabectedin - NIE TAG TA222
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Lung cancer (non-small-cell, advanced or metastatic maintenance treatment) - erlotinib (monotherapy) - NICE TAG TA227
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Multiple myeloma (first line) - bortezomib and thalidomide - NICE TAG TA228
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Leukaemia (chronic myeloid) - dasatinib, nilotinib, imatinib (intolerant, resistant) - NICE TAG TA241
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Colorectal cancer (metastatic) 2nd line - cetuximab, bevacizumab and panitumumab - NICE TAG TA242
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Breast cancer (advanced) - eribulin - NICE TAG TA250
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Leukaemia (chronic myeloid, first line) - dasatanib, nilotinib and standard-dose imatinib - NICE TAG TA251
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Prostate cancer - cabazitazel - NICE TAG TA255
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Breast cancer (metastatic hormone-receptor) - lapatinib and trastuzumab (with aromatase inhibitor) - NICE TAG TA257
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Lung cancer (non small cell, EGFR-TK mutation positive) - erlotinib (1st line) - NICE TAG TA258
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Bevacizumab in combination with capecitabine for the first-line treatment of metastatic breast cancer - NICE TAG TA263
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Melanoma (stage III or IV) - ipilimumab - NICE TAG TA268
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Melanoma (BRAF V600 mutation positive, unresectable metastatic) – vemurafenib - NICE TAG TA269
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Bevacizumab in combination with paclitaxel and carboplatin for first-line treatment of advanced ovarian cancer - NICE TAG TA284
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Ovarian, fallopian tube and primary peritoneal cancer (recurrent advanced, platinum-sensitive or partially platinum-sensitive) - bevacizumab - NICE TAG TA285
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Myelofibrosis (splenomegaly, symptoms) - ruxolitinib - NICE TAG TA289
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Guidance on the use of imatinib for chronic myeloid leukaemia - NICE TAG TA70
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Breast cancer (HER2 negative, oestrogen receptor positive, locally advanced or metastatic) - everolimus (with an aromatase inhibitor) - NICE TAG TA295
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Lung cancer (non-small-cell, anaplastic lymphoma kinase fusion gene, previously treated) - crizotinib NICE TAG TA296
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Leukaemia (chronic myeloid) - bosutinib NICE TAG TA299
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Macular oedema (central retinal vein occlusion) - aflibercept solution for injection NICE TAG TA305
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Colorectal cancer (metastatic) - aflibercept NICE TAG TA307
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Lung cancer (non small cell, EGFR mutation positive) - afatinib NICE TAG TA310
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Multiple myeloma - bortezomib (induction therapy) NICE TAG TA311
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Ipilimumab for previously untreated advanced (unresectable or metastatic) melanoma - NICE TAG TA319
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Dabrafenib for treating unresectable or metastatic BRAF V600 mutation‑positive melanoma - NICE TAG TA321
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Imatinib for the adjuvant treatment of gastrointestinal stromal tumours (review of NICE technology appraisal guidance 196) - NICE TAG TA326
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Axitinib for treating advanced renal cell carcinoma after failure of prior systemic treatment - NICE TAG TA333
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Pembrolizumab for treating advanced melanoma after disease progression with ipilimumab - NICE TAG TA357
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Ruxolitinib for treating polycythaemia vera (terminated appraisal) - NICE TAG 356
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Bevacizumab for treating relapsed, platinum‑resistant epithelial ovarian, fallopian tube or primary peritoneal cancer (terminated appraisal) - NICE TAG TA353
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Aflibercept for treating diabetic macular oedema - NICE TAG TA346
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Everolimus for preventing organ rejection in liver transplantation - NICE TAG TA348
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Nintedanib for previously treated locally advanced, metastatic, or locally recurrent non‑small‑cell lung cancer - NICE TAG TA347
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Regorafenib for metastatic colorectal cancer after treatment for metastatic disease (terminated appraisal) - NICE TAG TA334
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Idelalisib for treating follicular lymphoma that is refractory to 2 prior treatments (terminated appraisal) - NICE TAG TA328
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Pembrolizumab for treating advanced melanoma after disease progression with ipilimumab - NICE TAG 357
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Paclitaxel as albumin-bound nanoparticles with carboplatin for untreated non-small-cell lung cancer (terminated appraisal) - NICE TAG TA362
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Paclitaxel as albumin-bound nanoparticles in combination with gemcitabine for previously untreated metastatic pancreatic cancer - NICE TAG TA360
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Idelalisib for treating chronic lymphocytic leukaemia - NICE TAG TA359
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Pembrolizumab for advanced melanoma not previously treated with ipilimumab - NICE TAG TA366
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Trastuzumab emtansine for treating HER2-positive, unresectable locally advanced or metastatic breast cancer after treatment with trastuzumab and a taxane - NICE TAG TA371
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Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy - NICE TAG TA374
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Bortezomib for previously untreated mantle cell lymphoma - NICE TAG TA370
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Nintedanib for treating idiopathic pulmonary fibrosis - NICE TAG TA379
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Ramucirumab for treating advanced gastric cancer or gastro–oesophageal junction adenocarcinoma previously treated with chemotherapy - NICE TAG TA378
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Panobinostat for treating multiple myeloma after at least 2 previous treatments - NICE TAG TA380
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Olaparib for maintenance treatment of relapsed, platinum-sensitive, BRCA mutation-positive ovarian, fallopian tube and peritoneal cancer after response to second-line or subsequent platinum-based chemotherapy - NICE TAG TA381
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Ruxolitinib for treating disease-related splenomegaly or symptoms in adults with myelofibrosis - NICE TAG TA386
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Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer - NICE TAG TA389
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Nivolumab for treating advanced (unresectable or metastatic) melanoma - NICE TAG TA384
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Bosutinib for previously treated chronic myeloid leukaemia - NICE TAG TA401
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Ramucirumab for previously treated locally advanced or metastatic non-small-cell lung cancer - NICE TAG TA403
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Nivolumab in combination with ipilimumab for treating advanced melanoma - NICE TAG TA400
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Trametinib in combination with dabrafenib for treating unresectable or metastatic melanoma - NICE TAG TA396
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Cabazitaxel for hormone-relapsed metastatic prostate cancer treated with docetaxel - NICE TAG TA391
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Ceritinib for previously treated anaplastic lymphoma kinase positive non-small-cell lung cancer - NICE TAG TA395
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Crizotinib for untreated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer - NICE TAG TA406
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Pegaspargase for treating acute lymphoblastic leukaemia - NICE TAG TA408
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Talimogene laherparepvec for treating unresectable metastatic melanoma - NICE TAG TA410
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Necitumumab for untreated advanced or metastatic squamous non-small-cell lung cancer - NICE TAG TA411
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Trifluridine–tipiracil for previously treated metastatic colorectal cancer - NICE TAG TA405
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Cobimetinib in combination with vemurafenib for treating unresectable or metastatic BRAF V600 mutation-positive melanoma - NICE TAG TA414
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Osimertinib for treating locally advanced or metastatic EGFR T790M mutation-positive non-small-cell lung cancer - NICE TAG TA416
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Nivolumab for previously treated advanced renal cell carcinoma - NICE TAG TA417
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Everolimus with exemestane for treating advanced breast cancer after endocrine therapy - NICE TAG TA421
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Crizotinib for previously treated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer - NICE TAG TA422
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Eribulin for treating locally advanced or metastatic breast cancer after 2 or more chemotherapy regimens - NICE TAG TA423
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Pertuzumab for the neoadjuvant treatment of HER2-positive breast cancer - NICE TAG TA424
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Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia - NICE TAG TA425
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Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia - NICE TAG TA426
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Pembrolizumab for treating PD-L1-positive non-small-cell lung cancer after chemotherapy- NICE TAG TA428
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Pegylated liposomal irinotecan for treating pancreatic cancer after gemcitabine - NICE TAG TA440
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Cetuximab and panitumumab for previously untreated metastatic colorectal cancer - NICE TAG TA439
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Ibrutinib for previously treated chronic lymphocytic leukaemia and untreated chronic lymphocytic leukaemia with 17p deletion or TP53 mutation - NICE TAG TA429
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Everolimus for advanced renal cell carcinoma after previous treatment - NICE TAG TA432
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Nivolumab for treating relapsed or refractory classical Hodgkin lymphoma - NICE TAG TA462
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Carfilzomib for previously treated multiple myeloma - NICE TAG TA457
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Trastuzumab emtansine for treating HER2-positive advanced breast cancer after trastuzumab and a taxane - NICE TAG TA458
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Ibrutinib for untreated chronic lymphocytic leukaemia without a 17p deletion or TP53 mutation (terminated appraisal) - NICE TAG TA452
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Bortezomib for treating multiple myeloma after second or subsequent relapse (terminated appraisal) - NICE TAG TA453
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Daratumumab with lenalidomide and dexamethasone for treating relapsed or refractory multiple myeloma (terminated appraisal) - NICE TAG TA453
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Brentuximab vedotin for treating CD30-positive Hodgkin lymphoma - NICE TAG TA446
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Pembrolizumab for untreated PD-L1-positive metastatic non-small-cell lung cancer - NICE TAG TA447
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Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease - NICE TAG TA449
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Ponatinib for treating chronic myeloid leukaemia and acute lymphoblastic leukaemia - NICE TAG451
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Afatinib for treating advanced squamous non-small-cell lung cancer after platinum-based chemotherapy (terminated appraisal) - NICE TAG TA444
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Pegylated liposomal irinotecan for treating pancreatic cancer after gemcitabine - NICE TAG TA440
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Pembrolizumab for treating relapsed or refractory classical Hodgkin lymphoma - NICE TAG TA540
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Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine - NICE TAG TA535
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Idelalisib with ofatumumab for treating chronic lymphocytic leukaemia (terminated appraisal) - NICE TAG TA469
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Cabozantinib for previously treated advanced renal cell carcinoma - NICE TAG TA463
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Paclitaxel as albumin-bound nanoparticles with gemcitabine for untreated metastatic pancreatic cancer - NICE TAG TA476
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Sorafenib for treating advanced hepatocellular carcinoma - NICE TAG TA474
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Ibrutinib for treating Waldenstrom’s macroglobulinaemia - NICE TAG TA491
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Vismodegib for treating basal cell carcinoma - NICE TAG TA489
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Regorafenib for previously treated unresectable or metastatic gastrointestinal stromal tumours - NICE TAG TA488
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Venetoclax for treating chronic lymphocytic leukaemia - NICE TAG TA487
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Ibrutinib for treating relapsed or refractory mantle cell lymphoma - NICE TAG TA502
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Ceritinib for untreated ALK-positive non-small-cell lung cancer - NICE TAG TA500
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Lenvatinib with everolimus for previously treated advanced renal cell carcinoma - NICE TAG TA498
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Ixazomib with lenalidomide and dexamethasone for treating relapsed or refractory multiple myeloma - NICE TAG TA505
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Cabozantinib for treating medullary thyroid cancer - NICE TAG TA516
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Eribulin for treating locally advanced or metastatic breast cancer after 1 chemotherapy regimen - NICE TAG TA515
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Regorafenib for previously treated advanced hepatocellular carcinoma - NICE TAG TA514
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Daratumumab monotherapy for treating relapsed and refractory multiple myeloma - NICE TAG TA510
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Pertuzumab with trastuzumab and docetaxel for treating HER2-positive breast cancer - NICE TAG TA509
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Pembrolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapy - NICE TAG TA519
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Avelumab for treating metastatic Merkel cell carcinoma - NICE TAG TA517
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Atezolizumab for treating locally advanced or metastatic non-small-cell lung cancer after chemotherapy - NICE TAG TA520
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Arsenic trioxide for treating acute promyelocytic leukaemia - NICE TAG TA526
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Atezolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapy - NICE TAG TA525
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Brentuximab vedotin for treating CD30-positive Hodgkin lymphoma - NICE TAG TA524
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Midostaurin for untreated acute myeloid leukaemia - NICE TAG TA523
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Pembrolizumab for untreated PD-L1-positive locally advanced or metastatic urothelial cancer when cisplatin is unsuitable - NICE TAG TA522
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Pembrolizumab for untreated PD-L1-positive metastatic non-small-cell lung cancer - NICE TAG TA531
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Nivolumab for treating locally advanced unresectable or metastatic urothelial cancer after platinum-containing chemotherapy - NICE TAG TA530
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Crizotinib for treating ROS1-positive advanced non-small-cell lung cancer - NICE TAG TA529
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Niraparib for maintenance treatment of relapsed, platinum-sensitive ovarian, fallopian tube and peritoneal cancer - NIE TAG TA528
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Lutetium (177Lu) oxodotreotide for treating unresectable or metastatic neuroendocrine tumours - NICE TAG TA539
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Dinutuximab beta for treating neuroblastoma - NICE TAG TA538
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Alectinib for untreated ALK-positive advanced non-small-cell lung cancer - NICE TAG TA536
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Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine - NICE TAG TA535
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Inotuzumab ozogamicin for treating relapsed or refractory B-cell acute lymphoblastic leukaemia - NICE TAG TA541
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Pembrolizumab for treating relapsed or refractory classical Hodgkin lymphoma - NICE TAG TA540
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Cabozantinib for untreated advanced renal cell carcinoma - NICE TAG TA542
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Dabrafenib with trametinib for adjuvant treatment of resected BRAF V600 mutation-positive melanoma - NICE TAG TA544
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Gemtuzumab ozogamicin for untreated acute myeloid leukaemia - NICE TAG TA545
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Vandetanib for treating medullary thyroid cancer - NICE TAG TA550
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Pembrolizumab with pemetrexed and platinum chemotherapy for untreated, metastatic, non-squamous non-small-cell lung cancer - NICE TAG TA557
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Regorafenib for previously treated advanced hepatocellular carcinoma - NICE TAG TA555
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Pembrolizumab for adjuvant treatment of resected melanoma with high risk of recurrence - NICE TAG TA553
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Tisagenlecleucel for treating relapsed or refractory B-cell acute lymphoblastic leukaemia in people aged up to 25 years - NICE TAG TA554
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Lenvatinib for untreated advanced hepatocellular carcinoma - NICE TAG TA551
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Bevacizumab with carboplatin, gemcitabine and paclitaxel for treating the first recurrence of platinum-sensitive advanced ovarian cancer (terminated appraisal) - NICE TAG TA560
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Dabrafenib with trametinib for treating advanced metastatic BRAF V600E mutation-positive non-small-cell lung cancer (terminated appraisal) - NICE TAG TA 564
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Abemaciclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer - NICE TAG TA563
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Encorafenib with binimetinib for unresectable or metastatic BRAF V600 mutation-positive melanoma - NICE TAG TA562
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Venetoclax with rituximab for previously treated chronic lymphocytic leukaemia - NICE TAG TA561
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Bevacizumab with carboplatin, gemcitabine and paclitaxel for treating the first recurrence of platinum-sensitive advanced ovarian cancer (terminated appraisal) - NICE TAG TA560
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Brigatinib for treating ALK-positive advanced non-small-cell lung cancer after crizotinib - NICE TAG TA571
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Pembrolizumab for treating recurrent or metastatic squamous cell carcinoma of the head and neck after platinum-based chemotherapy (terminated appraisal) - NICE TAG TA570
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Pertuzumab for adjuvant treatment of HER2-positive early stage breast cancer - NICE TAG TA569
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Tisagenlecleucel for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic therapies - NICE TAG TA567
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Tisagenlecleucel for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic therapies - NICE TA TAG567
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Brentuximab vedotin for treating CD30-positive cutaneous T-cell lymphoma - NICE TAG TA577
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Bosutinib for untreated chronic myeloid leukaemia (terminated appraisal) - NICE TAG TA576
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Daratumumab with bortezomib and dexamethasone for previously treated multiple myeloma - NICE TAG TA573
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Cabozantinib for previously treated advanced hepatocellular carcinoma (terminated appraisal) - NICE TAG TA582
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Nivolumab with ipilimumab for untreated advanced renal cell carcinoma - NICE TAG TA581
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Abemaciclib with fulvestrant for treating hormone receptor-positive, HER2-negative advanced breast cancer after endocrine therapy - NICE TAG TA579
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Durvalumab for treating locally advanced unresectable non-small-cell lung cancer after platinum-based chemoradiation - NICE TAG TA578
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Atezolizumab in combination for treating metastatic non-squamous non-small-cell lung cancer - NICE TAG TA584
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8.2 Drugs affecting the immune response
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8.3 Sex hormones and hormone antagonists in malignant disease
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9 Nutrition and blood
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10 Musculoskeletal and joint diseases
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10.1 Drugs used in rheumatic diseases and gout
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10.1.1 Non-steroidal anti-inflammatory drugs
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10.1.2 Corticosteroids
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10.1.3 Drugs that suppress the rheumatic disease process
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Arthritis (juvenile idiopathic) - etanercept - NICE TAG TA35
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Rheumatoid arthritis - adalimumab, etanercept and infliximab - NICE TAG TA130
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Ankylosing spondylitis - adalimumab, etanercept and infliximab- NICE TAG TA143
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Rheumatoid arthritis - certolizumab pegol - NICE TAG TA186
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Rheumatoid arthritis - drugs for treatment after failure of a TNF inhibitor - NICE TAG TA195
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Psoriatic arthritis - etanercept, infliximab and adalimumab - NICE TAG TA199
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Certolizumab pegol and secukinumab for treating active psoriatic arthritis after inadequate response to DMARDs - NICE TAG445
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Psoriatic arthritis - golimumab - NICE TAG TA220
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Rheumatoid arthritis (after failure of previous anti-rheumatic drugs) - golimumab - NICE TAG TA225
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Ankylosing spondylitis - golimumab - NICE TAG TA233
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Arthritis (juvenile idiopathic, systemic) - tocilizumab - NICE TAG TA238
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Rheumatoid arthritis - tocilizumab - NICE TAG TA247
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Rheumatoid arthritis - abatacept (2nd line) (rapid review of TA234) - NICE TAG TA280
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Psoriatic arthritis (active) - ustekinumab NICE TAG TA313
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Apremilast for treating active psoriatic arthritis - NICE TAG TA372
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Abatacept, adalimumab, etanercept and tocilizumab for treating juvenile idiopathic arthritis - NICE TAG TA373
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Adalimumab, etanercept, infliximab, certolizumab pegol, golimumab, tocilizumab and abatacept for rheumatoid arthritis not previously treated with DMARDs or after conventional DMARDs only have failed - NICE TAG TA375
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TNF-alpha inhibitors for ankylosing spondylitis and non-radiographic axial spondyloarthritis - NICE TAG TA 383
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Belimumab for treating active autoantibody-positive systemic lupus erythematosus - NICE TAG TA397
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Secukinumab for active ankylosing spondylitis after treatment with non-steroidal anti-inflammatory drugs or TNF-alpha inhibitors - NICE TAG TA407
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Certolizumab pegol for treating rheumatoid arthritis after inadequate response to a TNF-alpha inhibitor - NICE TAG TA415
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Apremilast for treating active psoriatic arthritis - NICE TAG TA433
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Ustekinumab for moderately to severely active Crohn’s disease after previous treatment - NICE TAG TA456
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Baricitinib for moderate to severe rheumatoid arthritis - NICE TAG TA466
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Tofacitinib for moderate to severe rheumatoid arthritis - NICE TAG TA480
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Sarilumab for moderate to severe rheumatoid arthritis - NICE TAG TA485
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Ribociclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer - NICE TAG TA496
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Palbociclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer - NICE TAG TA495
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Golimumab for treating non-radiographic axial spondyloarthritis - NICE TAG TA497
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Autologous chondrocyte implantation using chondrosphere for treating symptomatic articular cartilage defects of the knee - NICE TAG TA508
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Tocilizumab for treating giant cell arteritis - NICE TAG TA518
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Tofacitinib for treating active psoriatic arthritis after inadequate response to DMARDs - NICE TAG TA543
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Abatacept for treating psoriatic arthritis after DMARDs (terminated appraisal) - NICE TAG TA568
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Tildrakizumab for treating moderate to severe plaque psoriasis - NICE TAG TA575
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Certolizumab pegol for treating moderate to severe plaque psoriasis - NICE TAG TA574
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10.1.4 Gout and cytotoxic-induced hyperuricaemia
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10.1.5 Other drugs for rheumatic diseases
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10.2 Drugs used in neuromuscular disorders
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10.3 Drugs for the treatment of soft-tissue disorders and topical pain relief
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Autologous chondrocyte implantation for treating symptomatic articular cartilage defects of the knee - NICE TAG TA477
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11 Eye
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12 Ear, nose, and oropharynx
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13 Skin
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14 Immunological products and vaccines
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15 Anaesthesia
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Miscellaneous
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New medicines / ACE
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Guidelines
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Shared care
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Wound care
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Patient Group Directions (PGDs)
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FAQs
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Further information
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Newsletters
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Referral forms
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Self Care
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Care Homes
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High Cost Drugs
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MTRAC
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COVID-19
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