NHS Dudley Health Economy Medicines Formulary
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13.10 Anti-infective skin preparations

General Guidance

  • Mupirocin is the topical antibiotic of choice for Gram positive infections. However, it should only be used if lesions are small and if it can be applied three times a day.
  • Superficial localised bacterial skin infections can be treated topically but widespread, deep (deeper than epidermal), severe l infections (e.g. streptococcal) should be treated with a systemic antibiotic (amoxycillin).
  • Topical antibiotics should be avoided on leg ulcers, treatment of bacterial colonisation is inappropriate.

Recommended drugs



Drug Traffic Light Key:

Green – On Formulary

Amber – Restricted use, see local guidelines      

Purple – Specialist use/initiation

Red – Non Formulary


Relative Costs Key (where indicated):

£££££ - high

£££ - moderate

£ - low

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