Leukaemia (lymphocytic) - fludarabine - NICE TAG TA29

1.1 Oral fludarabine is recommended as second line therapy for B-cell chronic lymphocytic leukaemia (CLL) for patients who have either failed, or are intolerant of, first line chemotherapy, and who would otherwise have received combination chemotherapy of either.

1.1.1 Cyclophosphamide, docorubicin, vincristine and prednisolone (CHOP)

1.1.2 Cyclophosphamie, docorubicin and prednisolone (CAP or

1.1.3 Cyclophosphamide, vincristine and prednisolone (CVP)

1.2 The oral formulation of fludarabine is preffered to the intravenous formualtion on the basis of more favourable cost effectiveness. Intravenous fludarabine should only be used when oral fludarabine is contra indicated.

https://www.nice.org.uk/guidance/TA29